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butabarbital will decrease the extent or result of doxorubicin liposomal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.butabarbital will lessen the level or result of midazolam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.For those who have been using this medicine for a long period,